Evaluation of portal hypertension and prognosis of patients with HIV/HCV co-infection through comtaminated blood product

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  • Takatsuki Mitsuhisa
    Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences
  • Eguchi Susumu
    Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences
  • Soyama Akihiko
    Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences
  • Kanematsu Takashi
    Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences
  • Nakao Kazuhiko
    Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences
  • Shirasaka Takuma
    AIDS Medical Center, National Hospital Organization Osaka National Hospital
  • Yamamoto Masahiro
    Department of Immunology and Infectious Diseases, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center
  • Gatanaga Hiroyuki
    AIDS Clinical Center, National Center for Global Health and Medicine
  • Tachikawa Natsuo
    Yokohama Municipal Citizen's Hospital
  • Kugiyama Yuki
    Clinical Research Center, National Hospital Organization Nagasaki Medical Center
  • Yatsuhashi Hiroshi
    Clinical Research Center, National Hospital Organization Nagasaki Medical Center
  • Ichida Takafumi
    Department of Gastroenterology and Hepatology, Shizuoka Hospital, University of Juntendo
  • Kokudo Norihiro
    Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo

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Other Title
  • 血液製剤によるHIV-HCV重複感染者の予後―肝移植適応に関する考察―
  • ケツエキ セイザイ ニ ヨル HIV-HCV チョウフク カンセンシャ ノ ヨゴ : カン イショク テキオウ ニ カンスル コウサツ

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Abstract

Background: As survival of HIV-infected persons has improved due to widespread use of antiretroviral therapy, mortality rate due to HCV-related liver disease has increased in HIV/HCV co-infected patients. Aim: To investigate the real status of portal hypertension and their prognosis in HIV/HCV co-infected patients. Patients and Methods: The data of 146 patients of HIV/HCV coinfection through blood product were extracted form 4 major HIV centers in Japan. In addition to liver function tests, palalet counts (PLT) were evaluated as a marker of portal hypertension. Results: In spite of maintained liver function tests such as albumin and bilirubin, platelet count was lowered less than 150,000/ul in 17 apatients. The prognosis was those lowered PLT patients were worse than that of patients with normal PLT. When compared with HCV monoinfected patients with PLT less than 150,000 ul, the prognosis of HIV/HCV co-infected patients were shorter. Conclusion: This fact must be taken into account to consider appropriate treatment including liver transplantation in HIV/HCV co-infected patients.<br>

Journal

  • Kanzo

    Kanzo 53 (10), 586-590, 2012

    The Japan Society of Hepatology

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