Stevens-Johnson syndrome induced by sorafenib for therapy of HCC: A case report
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- Yoshioka Teppei
- Department of Gastroenterology, Osaka Rosai Hospital
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- Yamada Yukinori
- Department of Gastroenterology, Osaka Rosai Hospital
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- Sueyoshi Hironao
- Department of Gastroenterology, Osaka Rosai Hospital
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- Yoshii Shunsuke
- Department of Gastroenterology, Osaka Rosai Hospital
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- Kawai Shoichiro
- Department of Gastroenterology and Hepatology, Osaka University Hospital
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- Okawa Masateru
- Department of Gastroenterology, Osaka Rosai Hospital
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- Hirao Motohiro
- Department of Gastroenterology, Osaka Rosai Hospital
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- Sato Masako
- Department of Gastroenterology, Osaka Rosai Hospital
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- Komori Masato
- Department of Gastroenterology, Osaka Rosai Hospital
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- Doi Toshiaki
- Department of Dermatology, Osaka Rosai Hospital
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- Yoshihara Harumasa
- Department of Gastroenterology, Osaka Rosai Hospital
Bibliographic Information
- Other Title
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- 肝細胞癌に対するソラフェニブ投与中にStevens-Johnson症候群を呈した1例
- ショウレイ ホウコク カン サイボウガン ニ タイスル ソラフェニブ トウヨ チュウ ニ Stevens-Johnson ショウコウグン オ テイシタ 1レイ
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Abstract
A 74-year-old Japanese male, suffering from stage IVA hepatocellular carcinoma (HCC) with subcarinal lymph node metastasis, was hospitalized for the sorafenib therapy. His hepatic reserve function was assessed as Child-Pugh score 5 and Liver damage grade A. Sorafenib was administered by 800 mg per day. On day 14, just after the development of fever, because erythematous lesions appeared in his trunk, the administration of sorafenib was immediately withdrawn under suspicion for erythema multiforme. However, on day 16, erythema expanded over his limbs and multiple erosions appeared in oral mucosa. Consequently, he was diagnosed as Stevens-Johnson syndrome and treated with prednisolone (20 mg/day). On day 31, his skin lesions disappeared and the fever went down, so prednisolone was withdrawn. When skin lesions are noticed during the sorafenib treatment, we should pay attention to Stevens-Johnson syndrome which is rare but serious, in addition to hand-foot skin reaction which is common for sorafenib.<br>
Journal
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- Kanzo
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Kanzo 53 (11), 741-747, 2012
The Japan Society of Hepatology
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Keywords
Details 詳細情報について
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- CRID
- 1390282679770064768
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- NII Article ID
- 10031127978
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- NII Book ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- NDL BIB ID
- 024103013
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed