Quantification of human serum ligandin by radioimmunoassay

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  • TSURU Masanoru
    The Second Department of Internal Medicine, University of Tokyo
  • HIRANO Masanori
    The Second Department of Internal Medicine, University of Tokyo
  • KAMISAKA Kazuaki
    The Second Department of Internal Medicine, University of Tokyo
  • KAMEDA Haruo
    The First Department of Internal Medicine, the Jikei University School of Medicine

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Other Title
  • ヒト血清リガンディンのRadioimmunoassay法による定量
  • ヒト ケッセイ リガンディン ノ Radioimmunoassayホウ ニヨル

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Abstract

A radioimmunoassay of the human serum ligandin was developed using rabbit antisera for ligandin purified from human liver. The normal value was 3.7±1.1 ng per ml, and higher values were obtained in the acute phase of various liver diseases. In patients with constitutional hyperbilirubinemia, the values were almost all within normal range. Serum ligandin concentrations and GPT activities were paralleled in acute and chronic hepatitis, but not in liver cirrhosis. These findings indicated that ligandinemia might be due to the release of ligandin from the damaged liver cells and that ligandin might not be involved in the impaired transfer mechanism of bilirubin in patients with constitutional hyperbilirubinemia.

Journal

  • Kanzo

    Kanzo 18 (12), 919-924, 1977

    The Japan Society of Hepatology

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