A case of Vp4 hepatocellular carcinoma with lung and brain metastases, successfully treated by multimodal therapy

Kanbara Yoshihiro, Yoshikawa Takuro, Tsuchida Shinobu, Ueno Kimihiko, Iwasaki Toshimitsu, Nakamura Takeshi, Hirohata Shigeya, Hanioka Keisuke, Fukamizu Machiko

doi:10.2957/kanzo.49.320

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Ｖｐ４肝細胞癌の肺・脳転移に対し集学的治療により著効が得られた１例
症例報告 Vp4肝細胞癌の肺・脳転移に対し集学的治療により著効が得られた1例
ショウレイホウコク Vp4 カンサイボウガンノハイノウテンイニタイシシュウガクテキチリョウニヨリチョコウガエラレタ 1レイ

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Abstract

Patient was a 66 years old man with hepatocellular carcinoma (HCC) complicated with tumor thrombus of the main trunk of portal vein (Vp4). Complete remission was obtained by continuous arterial infusion of low dose FP (CDDP+5-FU), followed by intermittent infusion of 5-FU at 750 mg per dose for 16 months. About 24 months after starting the therapy, however, multiple pulmonary metastases and solitary brain metastasis were recognized. He underwent a tumorectomy for the brain metastasis to improve the quality of life, while the multiple pulmonary metastases grew rapidly despite additional courses of systemic chemotherapy (5-FU+CDDP+EPI). Then, about 5 months after the relapse, all the chemotherapy was withdrawn and replaced by an oral administration of Juzen-taiho-to (TJ-48). Five months later, the serum levels of tumor markers (AFP and PIVKA II) had significantly decreased, and the lung tumors had disappeared on CT. Since then until now, the patient has been free from recurrence of HCC for more than 2 years. Because the pulmonary metastases presented an aggravation tendency at the withdrawal of chemotherapy, TJ-48 must have played an important role in the cure.<br>

Journal

Kanzo

Kanzo 49 (7), 320-326, 2008

The Japan Society of Hepatology

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