A male case of acute onset juvenile autoimmune hepatitis

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  • Tsukui Mamiko
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Jichi Medical University
  • Isoda Norio
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Jichi Medical University
  • Otake Toshiya
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Jichi Medical University
  • Higashisawa Toshihiko
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Jichi Medical University
  • Osawa Hiroyuki
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Jichi Medical University
  • Sato Shin
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Jichi Medical University
  • Sunada Fumiko
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Jichi Medical University
  • Ono Kazunori
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Jichi Medical University
  • Nagamine Nobuhiko
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Jichi Medical University
  • Ido Kenichi
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Jichi Medical University
  • Sugano Kentaro
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Jichi Medical University
  • Momoya Takayuki
    Department of Pediatrics, Jichi Medical University
  • Yotsumoto Shigeru
    Department of Pediatrics, Jichi Medical University
  • Tanaka Akira
    Department of Pathology, Jichi Medical University

Bibliographic Information

Other Title
  • 若年男性で急性発症した自己免疫性肝炎の１例
  • 症例報告 若年男性で急性発症した自己免疫性肝炎の1例
  • ショウレイ ホウコク ジャクネン ダンセイ デ キュウセイ ハッショウシタ ジコ メンエキセイ カンエン ノ 1レイ

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Abstract

We report a 13-years-old Japanese male with acute-onset autoimmune hepatitis (AIH). At the first laparoscopic observation, we could not find any characteristic features of AIH. The second laparoscopic observation revealed that the surface of liver had reddish markings and groove-like depression with atrophic changes. The third laparoscopic observation showed gentle undulation, reddish markings and patchy markings in his liver. Histologic examinations by the first biopsy specimens showed a zonal necrosis of the liver which was an atypical finding of AIH. Based on the international scoring system of AIH, we diagnosed this case as "probable AIH" and started predonizolone 40 mg per day. The laboratory data including serum IgG and anti-nuclear antibody were soon normalized after therapy and the dose of 5 mg per day of predonisolone has been maintained without relapse. We should consider AIH as a diagnostic possibility, whenever we see a patient presenting with unexplained liver dysfunction. <br>

Journal

  • Kanzo

    Kanzo 49 (5), 200-208, 2008

    The Japan Society of Hepatology

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