活性化マウス腹腔浸出細胞の腹水肝癌細胞(MH134)に対する細胞障害性

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タイトル別名
  • Anti-tumor activities of the activated macrophages in mice
  • カッセイカ マウス フククウ シンシュツ サイボウ ノ フクスイ カンガン サ

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LPS-stimulated peritoneal exudate cells exhibited a significantly potent anti-tumor activity in mice. A marked inhibition of DNA synthesis in tumor cells was observed when tumor cells were co-incubated with the activated peritoneal exudate cells. The inhibition of DNA synthesis in tumor cells was also shown by incubating tumor cells with the culture supernatant of activated peritoneal exudate cells. Interestingly, a different anti-tumor activity of the activated peritoneal exudate cells was observed by changing the combination of activated cells and target tumor cells in both parameters.<BR>The activated cells from C3H mice wete shown to have the more potent anti-tumor activity to hepatoma cells (MH134) than those from DD mice. Conversely, the activated cells from DD mice were more potent than those from C3H mice in inhibition of DNA synthesis of Ehrlich ascites tumor having singeneic origin of DD mice.

収録刊行物

  • 肝臓

    肝臓 21 (5), 562-566, 1980

    一般社団法人　日本肝臓学会

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