原発性肝癌の病理形態学的研究

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  • 岡部 正之
    久留米大学医学部第1病理学教室 久留米大学医学部第2外科学教室

書誌事項

タイトル別名
  • Patho-morphological studies on hepatocellular carcinoma
  • ゲンパツセイ カンガン ノ ビョウリ ケイタイガクテキ ケンキュウ カン サイ
  • A study on a mechanism of capsule formation and septum formation of tumor nodule
  • 肝細胞癌における癌結節の被膜並びに隔壁の形成機転について

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抄録

Encapsulated hepatocellular carcinoma is said to be much more frequent in Japan compared with United States and South Africa.<BR>There are several articles about capsule formation in hepatocellula carcinoma (HCC), but its mechanism has not yet been understood. In this study, 132 autopsy livers and 7 resected livers bearing HCC, obtained at Pathology Department, Kurume University School of Medicine from 1971 to 1977, were examined.<BR>1) Capsule formation was seen in 81 of the 139 cases (58.3%).<BR>2) There was no difference in the frequency of capsule formation between cases with and without liver cirrhosis.<BR>3) In advanced cirrhosis with minute HCC, capsule formation was more frequent (84.6%).<BR>4) Capsule results from collapse and collagenization of reticulin fibers following disappearance of liver cells due to compression by expansive growth of tumor.<BR>5) In all of the cases with capsule formation, intranodular septal formation was seen. There are two possible mechanisms for intranodular septal formation. Most of septa are a result of capsule formation that follows expansive growth of tumor over the capsle. Another explanation is the formation of septa by the collision of tumors of differing histologic pattern.<BR>6) Among the 17 cases showing type II according to Nakashima's classification, two or three histologically different patterns were seen in the one nodule in 8 cases.<BR>7) Many arterics and portal veins are seen around the tumor capsule and some portal veins are flattend. Tumor receives blood supply via arteries and arterial branches around the capsule.<BR>8) The angioarchtectular makeup was different in each area separated by intranodular septa, their histologic patterns was also different.

収録刊行物

  • 肝臓

    肝臓 20 (2), 144-156, 1979

    一般社団法人　日本肝臓学会

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