Morphological studies on the liver in a patient with drug-induced chronic intrahepatic cholcstasis

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Other Title
  • 薬剤に起因したと思われる慢性肝内胆汁うっ滞一症例の肝病理組織学的所見
  • ヤクザイ ニ キインシタ ト オモワレル マンセイ カンナイ タンジュウ ウッ
  • With special reference to abnormal findings of the bile duct
  • 肝内胆管系の病変を中心に

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Abstract

A patient, 52 year old woman, with chronic intrahepatic cholestasis, presumably due to drug, was reported. She complained of jaundice with Stevens-Johnson syndrome followingerythromycin and sulpyrin therapy against common cold-like symptom in Ocotber, 1976. Jaundice continues for longer than 3.5 years.<BR>Wedge biopsy specimen of the liver taken 8 months after the onset of jaundice revealed bile plugs in the centrilobular areas and accumulation of bile pigments in the liver cells and Kupffer cells with feathery degeneration of hepatocytes. Portal tracts were slightly enlarged with fibrous tissue. The most characteristic findings of her liver specimen was reduction of the interlobular bile duct (less than 74μ in diamter) in number, as compared with corresponding hepatic arterial branch. However, chronic non-suppurative destructive cholangitis was not observed.

Journal

  • Kanzo

    Kanzo 21 (11), 1551-1557, 1980

    The Japan Society of Hepatology

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