An autopsy case of subacute liver failure due to liver metastasis of breast cancer with the diffuse type

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  • Komura Takuya
    Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center
  • Ota Hajime
    Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center
  • Seishima Jun
    Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center
  • Nakai Ryotaro
    Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center
  • Miyazawa Masaki
    Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center
  • Marukawa Youhei
    Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center
  • Kagaya Takashi
    Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center
  • Furukawa Hiroyuki
    Department of Surgery, National Hospital Organization Kanazawa Medical Center
  • Kawashima Atsuhiro
    Department of Medical Laboratory, National Hospital Organization Kanazawa Medical Center
  • Unoura Masashi
    Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center

Bibliographic Information

Other Title
  • びまん浸潤型の乳がん肝転移により亜急性型の病型を呈した昏睡型急性肝不全の1剖検例
  • 症例報告 びまん浸潤型の乳がん肝転移により亜急性型の病型を呈した昏睡型急性肝不全の1剖検例
  • ショウレイ ホウコク ビマンシンジュンガタ ノ ニュウガン カン テンイ ニ ヨリ アキュウセイガタ ノ ビョウガタ オ テイシタ コンスイガタ キュウセイ カンフゼン ノ 1 ボウケンレイ

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Abstract

<p>A 55-year-old woman was admitted to our hospital with abdominal discomfort and liver injury. Laboratory evaluation showed liver injury with marked elevation of tumor markers. Computed tomographic scan showed liver swelling and diffuse uneven pattern in whole liver. Ascites was not detected. 2.5 cm right breast cancer was confirmed by needle biopsy species with axillary lymph node metastasis. She was diagnosis as having hepatic metastasis of breast cancer with the diffuse type. Since HER2 expression was positive in biopsy species, we treated with Trastuzumab, which is a monoclonal antibody for HER2. However, reserved function of the liver gradually worsened with the appearance of ascites in the 20th day of illness and hepatic coma in the 40th day of illness, and she was died of subacute type of liver failure in the 49th day of illness. The autopsy findings of the liver proved the diffuse type of metastasis of the breast cancer.</p>

Journal

  • Kanzo

    Kanzo 57 (7), 320-327, 2016

    The Japan Society of Hepatology

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