Efficacy of daclatasvir plus asunaprevir in elderly patients (>75 years of age) with chronic HCV genotype 1 infection
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- Aikawa Tatsuya
- Aikawa Internal Medicine Hospital
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- Ueno Chisato
- Aikawa Internal Medicine Hospital
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- Kikuchi Yohko
- Aikawa Internal Medicine Hospital
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- Tsuda Fumio
- Aikawa Internal Medicine Hospital
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- Ohnishi Hiroshi
- Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine
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- Okamoto Hiroaki
- Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine
Bibliographic Information
- Other Title
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- 高齢(>75歳)のC型慢性肝疾患患者に於けるDAA 2剤(DCV+ASV)治療の有効性
- コウレイ(>75サイ)ノ Cガタ マンセイ カン シッカン カンジャ ニ オケル DAA2ザイ(DCV+ASV)チリョウ ノ ユウコウセイ
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Description
<p>To investigate the efficacy of daclatasvir plus asunaprevir (DCV/ASV) in elderly patients (>75 years of age), 30 patients with chronic HCV genotype 1 infection, who had no resistant mutations in the HCV NS3/NS5A regions at baseline, including 11 patients aged 76-87 years, were treated with DCV/ASV for 24 weeks. Sustained virologic response 24 weeks after treatment (SVR24) was achieved by 28 (93%) of the 30 patients, with comparable SVR24 rates between the age groups of ≤75 years (95%, 18/19) and >75 years (91%, 10/11), and by 6 (86%) of 7 patients with compensated cirrhosis. These results suggest that DCV/ASV can achieve a high rate of SVR even in elderly patients (>75 years of age) without pre-existing NS3/NS5A resistant mutations.</p>
Journal
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- Kanzo
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Kanzo 57 (9), 499-501, 2016
The Japan Society of Hepatology
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Details 詳細情報について
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- CRID
- 1390282679770635136
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- NII Article ID
- 130005266156
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- NII Book ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- NDL BIB ID
- 027615855
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed