A case of childhood autoimmune hepatitis of cirrhotic stage manifested by anemia

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  • Muro Shinichiro
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Yasunaka Tetsuya
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Morimoto Yuuki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Ikeda Fusao
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Shiraha Hidenori
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Takaki Akinobu
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Nouso Kazuhiro
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Yamamoto Kazuhide
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Bibliographic Information

Other Title
  • 貧血を契機に発見され肝硬変に至っていた小児自己免疫性肝炎の1例
  • 症例報告 貧血を契機に発見され肝硬変に至っていた小児自己免疫性肝炎の1例
  • ショウレイ ホウコク ヒンケツ オ ケイキ ニ ハッケン サレ カンコウヘン ニ イタッテ イタ ショウニ ジコ メンエキセイ カンエン ノ 1レイ

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Abstract

A 15 years-old boy was pointed out anemia by the medical checkup. Further blood test revealed hepatobiliary enzymes abnormality. Computed tomography showed hepatosplenomegaly. He was diagnosed as autoimmune hepatitis (AIH) based on presence of anti-nuclear antibody and high level of IgG. He was treated with oral prednisolone (PSL: 20 mg/day) administration, and admitted to our hospital for further examination. We performed liver biopsy, and diagnosed as AIH of cirrhotic stage. The improvement of the liver dysfunction was insufficient. So he was treated with PSL: 40 mg/day and combined use of azathioprine, however these medications were still ineffective. Then, He was treated with pulsed methylpredonisolone (mPSL) therapy. Liver dysfunction improved after the treatment. This case is the boy who had neither abdominal symptoms nor jaundice and was diagnosed as AIH manifested by anemia. Because childhood AIH sometimes diagnosed as advanced stage, accurate diagnosis including liver biopsy and enough immunosuppression therapy is important.

Journal

  • Kanzo

    Kanzo 54 (10), 698-704, 2013

    The Japan Society of Hepatology

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