Reactivation of hepatitis B virus in a hepatitis B surface antigen-negative patient with membranous nephropathy treated with immunosuppression

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  • Ozono Yoshinori
    Department of Gastroenterology and Hematology, Miyazaki University
  • Hasuike Satoru
    Department of Gastroenterology and Hematology, Miyazaki University
  • Nagata Kenji
    Department of Liver Disease, Miyazaki University Hospital
  • Yamada Yuri
    Department of Gastroenterology and Hematology, Miyazaki University
  • Tsuchimochi Mai
    Department of Gastroenterology and Hematology, Miyazaki University
  • Nakamura Kenichi
    Department of Gastroenterology and Hematology, Miyazaki University
  • Shirado Akemi
    Department of Gastroenterology and Hematology, Miyazaki University
  • Kusumoto Kazunori
    Department of Internal Medicine, Koga Sougou Hospital
  • Iwakiri Hisayoshi
    Department of Gastroenterology and Hematology, Miyazaki University
  • Sato Yuji
    Department of Cardiology, Miyazaki University
  • Fujimoto Syoichi
    Departomet of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, Miyazaki University
  • Kitamura Kazuo
    Department of Cardiology, Miyazaki University
  • Samejima Naoki
    Department of Pathology, Faculty of Medicine, Miyazaki University
  • Shimoda Kazuya
    Department of Gastroenterology and Hematology, Miyazaki University Department of Liver Disease, Miyazaki University Hospital

Bibliographic Information

Other Title
  • 膜性腎症の治療経過中に発症したde novo B型肝炎の1例
  • ショウレイ ホウコク マクセイジンショウ ノ チリョウ ケイカ チュウ ニ ハッショウ シタ de novo Bガタ カンエン ノ 1レイ

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Abstract

A 75-year-old man receiving immunosuppressive therapy due to membranous nephropathy was admitted to our hospital with liver dysfunction in October 2011. Though laboratory data in November 2010 showed HB surface antigen negative, anti-HB surface antibody negative, anti-HB core antibody positive, on admission data showed HB surface antigen positive and HBV-DNA positive. He was diagnosed as de novo B hepatitis and administration of entecavir was started and his liver function recovered. Though reactivation of hepatitis B virus in the patients with renal diseases is rare, more attention should be paid when treating immunosuppressive therapy for patients with renal disease and further studies are needed.<br>

Journal

  • Kanzo

    Kanzo 54 (1), 74-80, 2013

    The Japan Society of Hepatology

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