肝組織像の経過を追えた中毒性表皮壊死症に合併した胆管消失症候群の1例

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  • A case of vanishing bile duct syndrome complicated with toxic epidermal necrolysis performed liver biopsy three times subsequently
  • ショウレイ ホウコク カン ソシキゾウ ノ ケイカ オ オエタ チュウドクセイ ヒョウヒ エシショウ ニ ガッペイ シタ タンカン ショウシツ ショウコウグン ノ 1レイ

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A 19-year-old Japanese woman who had high fever, systemic rashes, erosions and blisters was referred to our hospital. We diagnosed as a toxic epidermal necrolysis due to ibuprofen or acetaminophen based on the histopathology of skin biopsy, and started to administrate the intravenous methylprednisolone. Though the skin lesions improved soon after treatment, the hepatic dysfunction and jaundice continued. One month after admission, we diagnosed as vanishing bile duct syndrome complicated with toxic epidermal necrolysis through the result of liver histopathology. We observed on outpatient with administration of ursodeoxycholic acid, and the hepatic dysfunction and jaundice improved nine monthes after the first admission. In our case, we examined liver histopathology after the month and the six monthes and the eleven monthes after the first admission. Although almost bile ducts were disappeared in liver histopathology of the first biopsy, we observed the proliferation of regenerated bile ducts in histology of the second and the third biopsy. In care of toxic epidermal necrolysis, sometimes vanishing bile duct syndrome is known to be complicated, however it is rare to follow the clinical course of vanishing bile duct syndrome with the liver histopathology.<br>

収録刊行物

  • 肝臓

    肝臓 54 (1), 67-73, 2013

    一般社団法人　日本肝臓学会

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