Insulin-glucagon therapy on acute hepatitis

TANAKA Nobuyoshi, NODA Yatugi, HIRAI Nobuyuki, IKEDA Tadashi, OKAI Takashi, NAKAGAWA Hikohito, IWATA Akira, UNOURA Masashi, MORITA Nobuto, KUMAGAI Mikio, KAMEDA Shozi, NISHIMURA Keigo, KATO Yasuhiro, KOBAYASHI Kenichi, HATTORI Nobu

doi:10.2957/kanzo.21.1626

In order to evaluate the effect of insulin-glucagon (I-G) therapy on acute hepatitis, the present study was carried out on 2 cases of fulminant hepatitis (FH), 3 cases of subacute hepatitis (SH) and 8 cases of acute hepatitis (AH). These cases were treated with 10% glucose fluid (500ml) containing regular insulin (10 units) and glucagon (1mg). Normotest (NT), prothrombin time (PT), α₂-HS-glycoprotein and prealbumin were measured. In FH and SH, the mean values of NT remained less than 10%. In AH the mean values of NT increased after I-G therapy, but these values were decreased when I-G therapy was stopped. In FH and SH, PT remained prolonged and in AH, it was slightly shortened during I-G therapy. In FH and SH, the mean values of α₂-HS-glycoprotein remained less than 20mg/dl. In AH, the mean values were increased after I-G therapy. In FH and SH, the mean values of prealbumin were less than 5mg/dl. In AH, they increased, but these values were decreased when I-G therapy was stopped. From these results we suggest that I-G therapy may enhance the reserve of liver in acute hepatitis.

Insulin-glucagon therapy on acute hepatitis

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