A Case of Focal Nodular Hyperplasia of the Liver Associated with Female Sex Hormone Treatment

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  • FUJII Sachiyo
    Department of Internal Medicine (Metabology), Wakayama Prefectural University of Medicine
  • TSUJIOKA Etsuji
    Department of Internal Medicine (Metabology), Wakayama Prefectural University of Medicine
  • TAKEWA Mitsuo
    Department of Internal Medicine (Metabology), Wakayama Prefectural University of Medicine
  • YUKAWA Susumu
    Department of Internal Medicine (Metabology), Wakayama Prefectural University of Medicine
  • NOMOTO Hiroshi
    Department of Internal Medicine (Metabology), Wakayama Prefectural University of Medicine
  • NAGASAKI Yasuhiko
    Department of Internal Medicine (Digestive System), Wakayama Prefectural University of Medicine
  • OHSAWA Yuzo
    Department of Surgery (Digestive System), Wakayama Prefectural University of Medicine
  • TANAKA Tomoyuki
    1st Department of Pathology, Wakayama Prefectural University of Medicine

Bibliographic Information

Other Title
  • 女性ホルモン剤によると思われる肝nodular hyperplasiaの一症例
  • ジョセイ ホルモンザイ ニヨル ト オモワレル カン nodular hype

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Abstract

In this report, we proposed a case of a 25-year-old woman with large tumor of the liver. For approximately two years she received female sex hormones and other drugs to treat threatened abortion and to prevent infertility.<BR>On laboratory examination liver function tests were normal: α-fetoprotein was negative, but hepatic scintigram revealed enlargement of the right hepatic lobe with presumable cold areas and enlarged spleen. Exploratory laparotomy showed a large hepatic tumor which had developed from the underside of the right hepatic lobe and extended to the underside of left the lobe. It appeared to be massive and benign, but was not excisable; only biopsies were taken. Biopsies yielded histological findings of focal nodular liver-cell hyperplasia, not an adenoma.<BR>We suggested that female sex hormone may contribute to the liver-cell hyperplasia development. And, in view of the virtual absence of female hormone receptors in the liver, the hepatic action of female hormones may consist of an increase in prolactin receptors, a resultant increase in the hepatic action of prolactin, and also the effect of thyroid hormone.

Journal

  • Kanzo

    Kanzo 19 (6), 571-577, 1978

    The Japan Society of Hepatology

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