Hepatitis B-associated cryoglobulinemia and antiphospholipid antibodies

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  • Enomoto Masaru
    Department of Hepatology, Osaka City University Graduate School of Medicine
  • Negoro Nobuo
    Department of Clinical Immunology, Osaka City University Graduate School of Medicine
  • Fujii Hideki
    Department of Hepatology, Osaka City University Graduate School of Medicine
  • Kobayashi Sawako
    Department of Hepatology, Osaka City University Graduate School of Medicine
  • Iwai Shuji
    Department of Hepatology, Osaka City University Graduate School of Medicine
  • Morikawa Hiroyasu
    Department of Hepatology, Osaka City University Graduate School of Medicine
  • Tamori Akihiro
    Department of Hepatology, Osaka City University Graduate School of Medicine
  • Sakaguchi Hiroki
    Department of Hepatology, Osaka City University Graduate School of Medicine
  • Habu Daiki
    Department of Medical Nutrition, Osaka City University Graduate School of Life Science
  • Shiomi Susumu
    Department of Nuclear Medicine, Osaka City University Graduate School of Medicine
  • Kawada Norifumi
    Department of Hepatology, Osaka City University Graduate School of Medicine

Bibliographic Information

Other Title
  • ＨＢＶ関連クリオグロブリン血症における抗ホスファチジルセリン・プロトロンビン複合体抗体の意義
  • HBV カンレン クリオグロブリン ケツショウ ニ オケル コウホスファチジルセリン プロトロンビン フクゴウタイ コウタイ ノ イギ

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Description

A 57-year-old woman presented with a purpuric rash. Cryoglobulins were detected, and a skin biopsy showed leukocytoclastic vasculitis. The alanine aminotransferase level was 119 IU/L, and the platelet count 63,000/mm3. The hepatitis B virus (HBV) DNA was 6.4 log10 copies/mL and became negative by week 6 of entecavir therapy. The antiphosphatidylserine-prothrombin complex antibody (anti-PS/PT) was 390-510 U/mL, and decreased to 69 U/mL at week 24, after cryoglobulin had become negative and the rash resolved. Among 20 HBV-infected patients without extrahepatic manifestations, low titers of anti-PS/PT were detected in 8 (40%). Clinical characteristics were similar in patients with or without anti-PS/PT. Low titers of anti-PS/PT in chronic hepatitis B have little clinical significance, whereas high titers may promote cryoprecipitate formation.<br>

Journal

  • Kanzo

    Kanzo 51 (8), 454-456, 2010

    The Japan Society of Hepatology

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