A case of chronic hepatitis C reactivation and hepatocellular carcinoma after achievement of HCV RNA negative treated by combination therapy of IFN and ribavirin

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  • Yamada Norie
    Department of Internal Medicine, Center for Liver Diseases, Seizankai Kiyokawa Hospital Department of Virology II, National Institute of Infectious Diseases
  • Kobayashi Minoru
    Department of Internal Medicine, Center for Liver Diseases, Seizankai Kiyokawa Hospital
  • Okuse Chiaki
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine
  • Suzuki Michihiro
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine
  • Imai Yasuharu
    Department of Gastroenterology and Hepatology, Tokyo Medical University Hachioji Medical Center
  • Yotsuyanagi Hiroshi
    Department of Internal Medicine, Graduate School of Medicine, The University of Tokyo
  • Kato Takanobu
    Department of Virology II, National Institute of Infectious Diseases
  • Yasuda Kiyomi
    Department of Internal Medicine, Center for Liver Diseases, Seizankai Kiyokawa Hospital

Bibliographic Information

Other Title
  • ペグインターフェロン・リバビリン治療にて著効と判定された9年後にHCV陽性および肝細胞癌と診断された1例
  • 症例報告 ペグインターフェロン・リバビリン治療にて著効と判定された9年後にHCV陽性および肝細胞癌と診断された1例
  • ショウレイ ホウコク ペグインターフェロン ・ リバビリン チリョウ ニテ チョコウ ト ハンテイ サレタ 9ネンゴ ニ HCV ヨウセイ オヨビ カン サイボウ ガン ト シンダン サレタ 1レイ

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Abstract

The case was a 71-years-old man with chronic hepatitis C. He was treated by pegylated interferon (Peg-IFN) and ribavirin, and achieved HCV RNA negative. After 9 years, he developed chronic hepatitis with HCV and hepatocellular carcinoma. The pairwise comparison and phylogenetic analysis revealed that HCV strains isolated before (2004) and after (2015) treatment were closely related and considered to be progenies from same origin. By the highly sensitive HCV RNA detection kit (real-time PCR), HCV RNA was detected at the point of 24 weeks after treatment. These results suggested that HCV was not eradicated by Peg-IFN and ribavirin, and persistent infection of HCV contributed to the hepatocarcinogenesis. This case indicates that the long-term surveillance for HCV RNA with highly sensitive detection method is indispensable even after achievement of SVR.

Journal

  • Kanzo

    Kanzo 56 (11), 610-616, 2015

    The Japan Society of Hepatology

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