Interferon plus ribavirin therapy for coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV)

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  • B型肝炎ウイルス（HBV）とC型肝炎ウイルス（HCV）の重複感染例におけるインターフェロン，リバビリン併用療法
  • 症例報告 B型肝炎ウイルス(HBV)とC型肝炎ウイルス(HCV)の重複感染例におけるインターフェロン,リバビリン併用療法
  • ショウレイ ホウコク Bガタ カンエン ウイルス(HBV)ト Cガタカンエンウイルス(HCV)ノ チョウフク カンセンレイ ニ オケル インターフェロン,リバビリン ヘイヨウ リョウホウ

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Abstract

Coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) produces a higher incidence of cirrhosis and HCC development compared to monoinfection with either virus alone and therefore, aggressive treatment is preferred. Recently, pegylated interferon alpha plus ribavirin therapy was recommended as the treatment, but the information is not enough. We performed interferon plus ribavirin therapy for two cases of coinfection with HBV and HCV. In a case of HBe-Ag negative, a sustained virologic response (SVR) for HCV was achieved and HBs-Ag became negative. In the other case involving HBe-Ag positive, although SVR for HCV was achieved, severe hepatitis and liver fibrosis occurred due to rise of HBV activity during clearance of HCV, which was improved by adding nucleoside analogs. Treatment of coinfection with HBV and HCV should be selected after determine which virus is dominant. In some cases, the use of nucleoside analogs should be considered.<br>

Journal

  • Kanzo

    Kanzo 53 (8), 513-522, 2012

    The Japan Society of Hepatology

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