The effect of a multiple drug therapy with Inchinkoto, a herbal medicine on bile acids and bilirubin in two patients with prolonged severe mixed type of drug induced liver injury

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Other Title
  • 遷延した混合型薬物性肝障害に対して茵陳蒿湯を含む多剤薬物療法が有効であった2例
  • 症例報告 遷延した混合型薬物性肝障害に対して茵陳蒿湯を含む多剤薬物療法が有効であった2例
  • ショウレイ ホウコク センエン シタ コンゴウガタ ヤクブツセイ カン ショウガイ ニ タイシテ インチンコウトウ オ フクム タザイ ヤクブツ リョウホウ ガ ユウコウ デ アッタ 2レイ

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Abstract

Two adult males were admitted to our hospital because of the liver dysfunction with jaundice. Both patients had received tranilast to prevent keloid formation after the external injury. Liver biopsy revealed cholestatic liver injury in both cased. Drug-induced lymphocyte stimulation test for tranilast was negative in both cases. However, based on the absence of other causes of liver dysfunction, drug-induced liver injury was suspected. Ursodeoxycholic acid was administered, but it was not effective in both cases. We introduced Inchinkoto resulting in a remarkable improvement of liver dysfunction. Inchinkoto must be one of the therapeutic options for cholestatic liver injury.<br>

Journal

  • Kanzo

    Kanzo 53 (5), 291-297, 2012

    The Japan Society of Hepatology

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