A case of hepatitis C related cirrhosis with genotype 1b relapsed after combination therapy with Sofosbuvir and Ledipasvir

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Other Title
  • C型肝硬変に対しレジパスビル・ソホスブビル治療を行いRapid virological responseが得られたが再燃を来した1例
  • 症例報告 C型肝硬変に対しレジパスビル・ソホスブビル治療を行いRapid virological responseが得られたが再燃を来した1例
  • ショウレイ ホウコク Cガタ カンコウヘン ニ タイシ レジパスビル ・ ソホスブビル チリョウ オ オコナイ Rapid virological response ガ エラレタ ガ サイネン オ キタシタ 1レイ

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Abstract

<p>We report a case of hepatitis C related cirrhosis with genotype 1b with NS5A resistance-associated variants (RAVs). He was treated with the all-oral combination of the nucleotide polymerase inhibitor sofosbuvir (SOF) and the NS5A inhibitor ledipasvir (LDV) for 12 weeks. Although the HCV-RNA in his blood showed negative conversion four weeks after the start of treatment, it relapsed after the treatment for four weeks.</p><p>Previous reports that patients with baseline NS5A RAVs at baseline which treated with SOF/LDV had rates of SVR12 that were numerically and rates of virologic failure that were numerically higher than patients without NS5A RAVs.</p><p>We should pay attention to the NS5A RAVs at baseline in case of treatment for hepatitis C with SOF/LDV.</p>

Journal

  • Kanzo

    Kanzo 57 (8), 391-396, 2016

    The Japan Society of Hepatology

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