<SUP>99m</SUP>Tc-pyridoxylideneisoleucine (Pi)のラットに於ける肝・胆道系への排泄-特にsulfobromophthaleinによる干渉-

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タイトル別名
  • Inhibitory effect of sulfobromophthalein (BSP) on the hepatic uptake and biliary excretion of <SUP>99m</SUP>Tc-pyridoxylideneisoleucine (Pi) in rats
  • 99m Tc pyridoxylideneisoleucine Pi ノ ラッ

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Plasma clearance and biliary excretion of an iv injected 99mTc-pyridoxylideneisoleucine (Pi) were compared in control rats and in rats excreting sulfobromophthalein (BSP) into the bile at a maximal rate (Tm). Both plasma clearance and biliary excretion of 99mTc were delayed in rats made in a BSP Tm state compared with control rats. However, when the data were compared with the results previously reported for 99mTc-N-2, 6-(dimethylphenylcarbamoylmethyl) iminodiacetic acid (HIDA, K. Kitani, et al., Jap. J. Nucl. Med. 15: 999, 1978), the inhibitory effect of BSP was less prominent on biliary excretion and conversely, more striking on plasma clearance for 99mTc-Pi.

収録刊行物

  • 肝臓

    肝臓 20 (6), 604-609, 1979

    一般社団法人　日本肝臓学会

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