Response-guided therapy based on reaction to the initial dose using administration of peginterferon .ALPHA.-2a alone or in combination with ribavirin in naieve patients with chronic hepatitis C of serotype 2 and high viral loads
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- Kato Keizo
- Department of Gastroenterology, Narita Red Cross Hospital
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- Yonezawa Takeshi
- Department of Gastroenterology, Narita Red Cross Hospital
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- Tachibana Chizuko
- Department of Gastroenterology, Narita Red Cross Hospital
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- Tachibana Hiroyuki
- Department of Gastroenterology, Narita Red Cross Hospital
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- Watanabe Satoshi
- Department of Gastroenterology, Narita Red Cross Hospital
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- Mandai Yasushi
- Department of Gastroenterology, Narita Red Cross Hospital
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- Kashima Rei
- Department of Gastroenterology, Narita Red Cross Hospital
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- Fukuda Kazushi
- Department of Gastroenterology, Narita Red Cross Hospital
Bibliographic Information
- Other Title
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- Serotype 2型高HCVRNA量のC型慢性肝炎naieve症例における投与初期の反応性に基づいたPeginterferonα-2a単独もしくはRibavirin併用のResponse-Guided Therapy
- Serotype2型高HCVRNA量のC型慢性肝炎naive症例における投与初期の反応性に基づいたPeginterferonα-2a単独もしくはRibavirin併用のResponse-Guided Therapy
- Serotype2ガタ コウHCVRNAリョウ ノ Cガタ マンセイ カンエン naive ショウレイ ニ オケル トウヨ ショキ ノ ハンノウセイ ニ モトズイタ Peginterferona-2a タンドク モシクハ Ribavirin ヘイヨウ ノ Response-Guided Therapy
- Response-guided therapy based on reaction to the initial dose using administration of peginterferon α-2a alone or in combination with ribavirin in naïve patients with chronic hepatitis C of serotype 2 and high viral loads
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Abstract
Treatment with Peginterferon α-2a (PEG-IFNα2a) and α-2b (PEG-IFNα2b) was compared in naïve patients with chronic hepatitis C of serotype 2 and high viral loads (≥5 logIU/ml). In the PEG-IFNα2a group, PEG-IFNα2aα2a alone was administered for 24 weeks in patients negative for HCVRNA at week 4 (rapid viral response: RVR), while ribavirin (RBV) was added for patients who were still HCVRNA-positive at week 4 and given concomitantly with PEG-IFNα2a for further 24 weeks. In the PEG-IFNα2b group, RBV was administered concomitantly with PEG-IFNα2b for 24 weeks. The sustained virological response rates were 93.3% and 66.7% in the PEG-IFNα2a and PEG-IFNα2b groups, respectively, and PEG-IFNα2a alone or in combination with RBV gave similar results to PEG-IFNα2b+RBV. No patients in the PEG-IFNα2a group required discontinuation of administration due to adverse effects. Response-guided therapy based on RVR may be an effective and practical strategy with high efficacy, reduced costs, and fewer adverse events.<br>
Journal
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- Kanzo
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Kanzo 53 (1), 18-27, 2012
The Japan Society of Hepatology
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Keywords
Details 詳細情報について
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- CRID
- 1390282679771916032
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- NII Article ID
- 10030240761
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- NII Book ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- NDL BIB ID
- 023404473
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed