Effect of ornithine-aspartate and vitamine B<SUB>6</SUB> on lipid synthesis in ethanol treated mice

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  • NAKAMURA Haruo
    Department of Oral Physiology, Hokkaido University School of Dentistry
  • ISHIKAWA Masako
    Department of Oral Physiology, Hokkaido University School of Dentistry

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Other Title
  • エタノールによる肝脂質生合成に対するオルニチンアスパルテートおよびビタミンB<SUB>6</SUB>の作用
  • エタノール ニヨル カン シシツ セイゴウセイ ニ タイスル オルニチンアスパ

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Description

An increase of blood and liver total cholesterol by ethanol did not affect by the joint use of ornithine-aspartate and vitamine B6.<BR>However, the joint use of ornithine-aspartate and vitamine B6 had an inhibitory effect on the increase in biosynthesis of fatty acid and on the decrease in biosynthesis of cholesterol by ethanol.<BR>When ornithine-aspartate or vitamine B6 alone was administered in normal mice, a decrease in the incorporation of acetate-1-14C into cholesterol and an increase in the incorporation of acetate into fatty acid were seen.<BR>On the metabolic rate of ethanol, the disappearance rate of blood ethanol is more rapid in the ornithine-aspartate treated mice and in mice pretreated with ornithine-aspartate, the metabolic rate of ethanol in liver was higher.<BR>From the above result, it may be said that the joint use of ornithine-aspartate and ornithine-aspartate plus vitamine B6 normalize partially ethanol induced liver lipid synthesis.

Journal

  • Kanzo

    Kanzo 16 (8), 488-494, 1975

    The Japan Society of Hepatology

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