Assessment of liver elasticity and viscosity using ultrasound shear wave dispersion: a study of hepatic fibrosis and inflammation in a rat model

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  • Sugimoto Katsutoshi
    Department of Gastroenterology and Hepatology, Tokyo Medical University
  • Moriyasu Fuminori
    Department of Gastroenterology and Hepatology, International University of Health and Welfare, Sanno Hospital
  • Oshiro Hisashi
    Department of Pathology, Jichi Medical University
  • Yoshimasu You
    Department of Gastroenterology and Hepatology, Tokyo Medical University
  • Takeuchi Hirohito
    Department of Gastroenterology and Hepatology, Tokyo Medical University
  • Kasai Yoshitaka
    Department of Gastroenterology and Hepatology, Tokyo Medical University
  • Furuichi Yoshihiro
    Department of Gastroenterology and Hepatology, Tokyo Medical University
  • Kobayashi Yoshiyuki
    Department of Gastroenterology and Hepatology, Tokyo Medical University
  • Nakamura Ikuo
    Department of Gastroenterology and Hepatology, Tokyo Medical University
  • Itoi Takao
    Department of Gastroenterology and Hepatology, Tokyo Medical University

Bibliographic Information

Other Title
  • 超音波Shear Wave Dispersion Imagingによる肝の弾性と粘性の測定
  • チョウオンパ Shear Wave Dispersion Imaging ニ ヨル カン ノ ダンセイ ト ネンセイ ノ ソクテイ

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Description

<p>To investigate the value of shear wave (SW) speed (m/s) and dispersion slope ([m/s]/kHz), which is related to viscosity obtained by a prototype ultrasound elastography system in rat livers with various degrees of inflammation and fibrosis. SW speed was significantly higher in the fibrosis model rats (G3) than in the inflammation model rats (G1). Dispersion slope was significantly higher in the inflammation model rats (G2) than in the fibrosis model rats (G4). These results indicate that SW speed is more effective than dispersion slope in assessing the degree of fibrosis and also suggest that dispersion slope is more effective than SW speed in assessing the degree of inflammation. Dispersion slope measurements may provide additional pathophysiological insights into liver tissue.</p>

Journal

  • Kanzo

    Kanzo 58 (9), 536-539, 2017

    The Japan Society of Hepatology

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