Ultrastructural Changes of the Hepatocytes in Human Fulminant Hepatitis

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  • NAGATA Eisuke
    Second Department of Internal Medicine, School of Medicine, Kurume University
  • IKEJIRI Naoki
    Second Department of Internal Medicine, School of Medicine, Kurume University
  • MAEYAMA Toyoaki
    Second Department of Internal Medicine, School of Medicine, Kurume University
  • EGUCHI Takahisa
    Second Department of Internal Medicine, School of Medicine, Kurume University
  • KAWAGUCHI Motonari
    Second Department of Internal Medicine, School of Medicine, Kurume University
  • ABE Hirohiko
    Second Department of Internal Medicine, School of Medicine, Kurume University
  • TANIKAWA Kyuichi
    Second Department of Internal Medicine, School of Medicine, Kurume University

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Other Title
  • 劇症肝炎の肝細胞の電顕的観察
  • ゲキショウ カンエン ノ カン サイボウ ノ デンケンテキ カンサツ

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Abstract

Biopsy specimen taken from three patients of fulminant hepatitis were examined under electron microscope. The most striking finding of the two cases of early stage of fulminant hepatitis was an accumulation of numerous small fat droplets with severely damaged mitochondria in the cytoplasma of the hepatocytes. This finding was similar to one of Reye's syndrome. The hepatocytes undergoing coagulation necrosis also contained these fat drop1ets. In the necrotic area, there were many cell debris, macrophages, lymphocytes and fat-storing cells with new collagen formation. In addition, small hepatocytes were often noted in the peripheral part of the lobule. They are probably regenerative hepatocytes because of their well preserved organelles.

Journal

  • Kanzo

    Kanzo 19 (8), 717-724, 1978

    The Japan Society of Hepatology

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