The clinical and immunopathogenic significance of serum cryoglobulins in various liver diseases

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  • 肝疾患における血中cryoglobulinの検出とその病態生理学的意義
  • カン シッカン ニ オケル ケッチュウ cryoglobulin ノ ケンシュ

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Serum cryoglobulins levels were measured in 127 patients with various liver diseases and 30 healthy individuals. Serum contents of cryoglobulins in normal controls were less than 0.6mg/dl and then those more than 1 mg/dl in sera were defined to be hypercryoglobulinemia.<BR>Hypercryoglobulinemia were detected in the sera from 3 of 22 patients with acute hepatitis (14%), 9 of 32 chronic hepatitis (28%), 14 of 24 liver cirrhosis (61%), 6 of 7 P.B.C. (86%), and 1 of 6 asymptomatic carrier (17%).<BR>Cryoprecipitates consisted of mixed cryoimmunoglobulin (1gM, 1gG and/or 1gA) and also contained HBs·Ag and/or HBs·Ab.<BR>It was noted that HBs·Ag was detected in their cryoprecipitates in 2 out of 20 HBs·Ag negative patlents.<BR>Hypercryoglobulinemia was frequently encountered in the patients with serum sicknesS like syndrome, such as arthralgia, purpura, rash and nephropathy.<BR>Hypercryoglobulinemia was observed in the patients with hyperglobulinemia, decreased hepatic clearance of 198Au colloid or low levels of serum complements.

Journal

  • Kanzo

    Kanzo 19 (5), 471-478, 1978

    The Japan Society of Hepatology

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