活動性慢性肝疾患における血中抗肝細胞膜抗体に関する研究

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タイトル別名
  • Studies on the Humoral Anti-Hepatocyte Membrane Antibody in Active Chronic Hepatitis
  • カツドウセイ マンセイ カン シッカン ニ オケル ケッチュウ コウカン サイボウマク コウタイ ニ カンスル ケンキュウ

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抄録

Anti-hepatocyte membrane antibody (AHMA) was investigated in 69 patients with active chronic hepatitis and other liver diseases by membrane immunofluorescence method.<BR>AHMA from rabbits immunized with liver specific membrane lipoprotein (Meyer zum Buschenfelde) showed linear membrane fluorescence on isolated rat hepatocytes.<BR>Investigation of sera from patients showed two different immunofluorescence patterns, i.e. linear pattern and granular one. Each of them seemed to represent AHMA and anti-smooth muscle antibody respectively.<BR>AHMA could be demonstrated in 46% of the patients with active chronic hepatitis and in 55% of the patients with lupoid hepatitis. There was no correlation between the presence of AHMA and HBsAg.<BR>These findings support the possibility that antibody dependent cell-mediated cytotoxicity may be involved in the pathogenesis of active chronic hepatitis.

収録刊行物

  • 肝臓

    肝臓 19 (6), 541-546, 1978

    一般社団法人　日本肝臓学会

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