Studies on Serum Lactic Dehydrogenase Isoenzyme in Hepatic Diseases

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  • NOMA Keisuke
    The First Department of Internal Medicine Okayama University Medical School

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Other Title
  • 肝疾患における血清LDH zymogramの検討
  • カン シッカン ニ オケル ケッセイ LDH zymogram ノ ケントウ

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Description

LDH zymograms of sera from patients with hepatic disorders were studied by using a technique of agar-gel electrophoresis. Elevated activities of LDH5 were frequently observed in various liver diseases. In acute hepatitis, LDH5 activities still elevated even after the serum total LDH activities returned to the normal level in the recovery stage. In primary hepatoma, activities of LDH5 showed a tendency to be higher than those of LDH4. On the other hand, in metastatic liver cancer activities of LDH3 as well as LDH4 were increased distinctly, and activities of LDH4 appeared to be higher than those of LDH5. Therefore, the differences of the zymographic patterns of LDH between primary and metastatic liver cancer seemed to be useful for differentiating the both types of liver cancer.

Journal

  • Kanzo

    Kanzo 16 (9), 587-596, 1975

    The Japan Society of Hepatology

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