内視鏡的食道静脈瘤硬化療法後の血清コリンエステラーゼ活性上昇に関する検討

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タイトル別名
  • Unexpected elevation of serum cholinesterase activities after endoscopic injection sclerotherapy for esophageal varix in cirrhosis patients
  • ナイシキョウテキ ショクドウ ジョウミャクリュウ コウカ リョウホウ ゴ ノ ケッセイ コリンエステラーゼ カッセイ ジョウショウ ニ カンスル ケントウ

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説明

Since Oct 2006, we experienced 10 cirrhosis patients showing the unexpected elevation of cholinesterase (ChE) activity after endoscopic injection sclerotherapy (EIS) for esophageal varix. Comparing these patients with the six patients who did not show the elevation of the enzyme, we found that in former patients haptoglobin was infused after EIS to avoid hemolysis. Haptoglobin is a blood-born product and contaminated with ChE whose chemical properties is similar to those of haptoglobin. Moreover, manufacturer altered their processing system since Oct 2004, which deteriorated the contamination. We conclude that the contaminated ChE activity in haptoglobin raised serum ChE activities in cirrhosis patients who had EIS for esophageal varix.<br>

収録刊行物

  • 肝臓

    肝臓 52 (12), 784-786, 2011

    一般社団法人　日本肝臓学会

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