A case report of perforation of the colon during the sorafenib therapy for hepatocellular carcinoma
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- Nakayama Nana
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Aikata Hiroshi
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Kawaoka Tomokazu
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Murakami Eisuke
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Miyaki Daisuke
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Nagaoki Yuko
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Hashimoto Yoshimasa
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Azagami Takahiro
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Takaki Shintaro
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Tsuge Masataka
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Waki Koji
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Hiramatsu Akira
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Imamura Michio
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Hyogo Hideyuki
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Kawakami Yoshiiku
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Takahashi Syoichi
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
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- Shimizu Wataru
- Department of Gastroenterological Surgery, Hiroshima University Hospital
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- Arihiro Koji
- Department of Anatomical Pathology, Hiroshima University Hospital
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- Cyayama Kazuaki
- Department of Gastroenterological and Metabolic Medicine, Hiroshima University Hospital
Bibliographic Information
- Other Title
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- Ｓｏｒａｆｅｎｉｂ内服中に腸管穿孔を合併した肝細胞癌の１例
- 症例報告 Sorafenib内服中に腸管穿孔を合併した肝細胞癌の1例
- ショウレイ ホウコク Sorafenib ナイフク チュウ ニ チョウカン センコウ オ ガッペイ シタ キモ サイボウガン ノ 1レイ
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Description
A 72-year-old man who has suffered from advanced hepatocellular carcinoma (HCC) with lung and chest wall metastasis was treated with sorafenib by a dose of 800 mg/day. Because of hand-foot-skin reaction, dosage was reduced to 400 mg/day on day 11. After 7 months, sorafenib was transiently discontinued because of a diarrhea and a fatigue for one month. After disappearance of symptoms, sorafenib was restarted by a dose of 400 mg/day. One month after that he admitted due to the lower abdominal pain. Abdominal CT scan revealed free gas in the pelvis. An emergency operation was performed based on the diagnosis of perforation and diverticulitis of the sigmoid colon. He is currently well. Here we report a case of perforation of the colon during the sorafenib therapy for advanced HCC.<br>
Journal
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- Kanzo
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Kanzo 52 (12), 777-783, 2011
The Japan Society of Hepatology
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Details 詳細情報について
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- CRID
- 1390282679772472704
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- NII Article ID
- 10030240677
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- NII Book ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- NDL BIB ID
- 023366729
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
