Chronic hepatitis B which converting to HBs antigen negativity and HBs antibody positivity during Peg-IFNα-2a treatment after surgery for hepatocellular carcinoma: a case report

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  • Mimura Shima
    Department of Gastroenterology and Neurology Faculty of Medicine, Kagawa University
  • Tani Joji
    Department of Gastroenterology and Neurology Faculty of Medicine, Kagawa University
  • Oura Kyoko
    Department of Gastroenterology and Neurology Faculty of Medicine, Kagawa University
  • Tadokoro Tomoko
    Department of Gastroenterology and Neurology Faculty of Medicine, Kagawa University
  • Fujita Koji
    Department of Gastroenterology and Neurology Faculty of Medicine, Kagawa University
  • Sakamoto Teppei
    Department of Gastroenterology and Neurology Faculty of Medicine, Kagawa University
  • Nomura Takako
    Department of Gastroenterology and Neurology Faculty of Medicine, Kagawa University
  • Miyoshi Hisaaki
    Department of Gastroenterology and Neurology Faculty of Medicine, Kagawa University
  • Morishita Asahiro
    Department of Gastroenterology and Neurology Faculty of Medicine, Kagawa University
  • Yoneyama Hirohito
    Department of Gastroenterology and Neurology Faculty of Medicine, Kagawa University
  • Himoto Takashi
    Department of Medical Technology, Kagawa Prefectural University of Health Sciences
  • Okano Keiichi
    Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University
  • Murota Masayuki
    Department of Internal Medicine, Kaisei Hospital
  • Ogawa Chikara
    Department of Gastroenterology, Takamatsu Red Cross Hospital
  • Takaguchi Kouichi
    Department of Hepatology, Kagawa Prefectural Central Hospital
  • Miyai Yumi
    Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University
  • Haba Reiji
    Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University
  • Suzuki Yasuyuki
    Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University
  • Masaki Tsutomu
    Department of Gastroenterology and Neurology Faculty of Medicine, Kagawa University

Bibliographic Information

Other Title
  • 肝発癌後にPeg-IFNα-2a投与によりHBs抗原陰性化；HBs抗体陽性化が得られたB型慢性肝炎の1例
  • 症例報告 肝発癌後にPeg-IFNα-2a投与によりHBs抗原陰性化 : HBs抗体陽性化が得られたB型慢性肝炎の1例
  • ショウレイ ホウコク カンハツガン ゴ ニ Peg-IFNa-2a トウヨ ニ ヨリ HBs コウゲン インセイカ : HBs コウタイ ヨウセイカ ガ エラレタ Bガタ マンセイ カンエン ノ 1レイ

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Abstract

<p>A 51-year-old woman with chronic hepatitis B monitored in our department since 2001 was found in 2010 to have an HBV DNA level was 4 log copies/ml and an ALT 31 U/L. She was diagnosed with non-active hepatitis B and followed up without antivirus therapy. Contrast-enhanced CT in 2013 showed a hepatocellular carcinoma, for which she underwent laparoscopic resection of the S8 subregion of the liver. Pathologic examination showed a scirrhous type hepatocellular carcinoma, with the non-cancerous region in an F1 state of fibrosis. One month later, she was started on Peg-IFN α-2a to induce hepatitis B surface antigen negativity and prevent tumor recurrence. HBV DNA and HBs antigen became undetectable after 24 weeks, respectively, whereas HBs antibody became positive at 48 weeks. These findings suggest that patients with low HBs antigen concentration (100 IU/ml) and low, HBV DNA may convert to HBs antigen negativity following Peg-IFN treatment.</p>

Journal

  • Kanzo

    Kanzo 57 (12), 666-673, 2016

    The Japan Society of Hepatology

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