Studies on the HBsAg and HBcAg in the liver tissue

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  • KIYOSAWA Kendo
    The second Department of Internal Medicine, Shinshu University Medical School

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Other Title
  • 肝組織内HBs抗原・HBc抗原に関する研究
  • カン ソシキナイ HBs コウゲン HBc コウゲン ニカンスルケンキュウ 2
  • Part 2. Studies on the intrahepatic HBsAg and HBcAg expression of various liver diseares and on the changes of the intrahepatic HBsAg expression of the cases developping hepatitis from asymptomatic
  • 第2編:各種肝疾患における肝組織内HBs抗原・HBc抗原の検討およびAsymptomatic HBsAg Carrierより肝炎発症例における肝組織内HBs抗原の変動について

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Description

Intrahepatic HBsAg and HBcAg expression in patients of asymptomatic HBsAg carriers (25 cases), type B acute hepatitis (18cases), type B chronic liver diseases (95cases), and blood disorders with immunosuppressant therapy (2cases) were examined by immunofluorescent method.In asymptomatic HBsAg carriers, membranous localization pattern of intrahepatic HBsAg expression was characteristic finding and few intrahepatic HBcAg was detected. In type B chronic liver diseases, intrahepatic HBsAg expression were mixed, cytoplasmic localization pattern and fbcal, sporadic distribution pattern, and intrahepatic HBcAg were detected abundantly. In patients of blood dirorders with immunosuppressant therapy, intrahepatic HBcAg were detected most abundantly. In fluminant hepatitis, intrahepatic HBsAgand HBcAg were not detected. In acute hepatitis with good prognosis, HBsAg were detected a little but HBcAg were not detected, In two patients developping hepatitis from asymptomatic HBsAg carriers, intrahepatic HBsAg expression changed to cytoplasmic pattern from membranous pattern.<BR>Intrahepatic HBsAg and HBcAg expression were variable according tograde of hepatic injury and its development.

Journal

  • Kanzo

    Kanzo 19 (2), 148-161, 1978

    The Japan Society of Hepatology

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