Genetic Background of Neuroblastoma IV-S : Inspection on Knudson's Hypothesis
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- Sawaguchi Shigenori
- Department of Pediatric Surgery, The University of Tsukuba
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- Yamazaki Yoji
- Department of Pediatric Surgery, The University of Tsukuba
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- Suganuma Yasushi
- Department of Pediatric Surgery, The University of Tsukuba
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- Watanabe Itaru
- 2nd Department of Surgery, Tohoku University School of Medicine
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- Takahashi Hideyo
- Department of Pediatric Surgery, Chiba University School of Medidine
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- Tsuchida Yoshiaki
- Department of Pediatric Surgery, University of Tokyo, School of Medicine
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- Kinumaki Hiroshi
- Department of Pediatrics, University of Tokyo, School of Medicine
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- Okabe Ikuo
- 1st Department of Surgery, Nihon University School of Medicine
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- Taguchi Nobuyuki
- Department of Pediatrics, National Children's Hospital
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- Ise Yasushi
- Department of Pediatrics, National Cancer Center Hospital
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- Tsunoda Akio
- Department of Surgery, Kanagawa Children's Medical Center
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- Tsunooka Hidehiko
- 2nd Department of Surgery, Nagoya City University Medical School
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- Sawada Tadashi
- Department of Pediatrics, Kyoto Prefectural University of Medicine
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- Ueda Takashi
- Surgical Department, Children's Medical Center of Osaka City
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- Muta Hiroo
- 1st Department of Surgery, Nagasaki University School of Medicine
Bibliographic Information
- Other Title
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- 神経芽腫 IV-S 症例の遺伝学的背景 : Knudson 理論の検証
- シンケイガシュ IV-S ショウレイ ノ イデンガクテキ ハイケイ Knuds
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Description
Genetic background of neuroblastoma IV-S was studied, based upon the data on 380 cases of neuroblastomata, collected from 11 main facilities in Japan. Among 380 cases collected, 16 belonged to the group neuroblastoma IV-S. All the IV-S cases had the onset before 12 months. This is remarkably earlier than any other stages of this disease. There was no case with multiple origin of the tumor in this collected series of IV-S. But one case of IV-S with bilateral adrenal origin was experienced in the Pediatric Surgical Department of Tsukuba University, and moreover there were some reports on multiple origin in the literature. The familial occurrence rate of neuroblastoma IV-S was 1/16 (6.3%), while that of other stages were 1/364 (0.3%). The young onset and multiplicity, which were demonstrated as two important characteristics of familial tumor by Knudson, were well proven in the neuroblastoma IV-S in this study.
Journal
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- Journal of the Japanese Society of Pediatric Surgeons
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Journal of the Japanese Society of Pediatric Surgeons 17 (6), 1053-1057, 1981
The Japanese Society of Pediatric Surgeons
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Details 詳細情報について
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- CRID
- 1390282679782577792
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- NII Article ID
- 110002095748
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- NII Book ID
- AN00192281
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- ISSN
- 21874247
- 0288609X
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- NDL BIB ID
- 2362124
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed