Synthesis of HIV Vaccine Model Based on Lactose-Functionalized Poly(lysine) Dendrimer Scaffold
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- Baigude Huricha
- Department of Enviromental and Material Engineering, Teikyo Unuversity of Science & Technology
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- Katsuraya Kaname
- Wayo Womens' University
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- Okuyama Kohsaku
- Institute of Industrial Science, University of Tokyo
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- Kariya Naoki
- Department of Enviromental and Material Engineering, Teikyo Unuversity of Science & Technology
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- Uryu Toshiyuki
- Department of Enviromental and Material Engineering, Teikyo Unuversity of Science & Technology
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A series of HIV vaccine models based on lactose-bound poly(lysine) scaffolds was synthesized. A spherical poly(lysine) dendrimer was prepared to bind lactose at the peripheral through reductive amination. Lactose-poly(lysine) dendrimers with the degree of substitution (DS) varying from 5 to 19 were obtained by controlling the feeding ratio of lactose to the poly(lysine) dendrimer. Three succinylated compounds such as succinyl monobenzylate, ethyl-phenylalanyl succinylamide and succinyl-L-alanyl-L-prolyl-L-alanine p-nitroanilide which were regarded as antigen peptide models were bound to the lactose-poly(lysine) dendrimer through esterification between the carboxyl group of the succinyl moiety and the 6-OH group of the lactose residue. The DS of resulting vaccine models was investigated by NMR spectra analyses.
収録刊行物
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- 繊維学会誌
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繊維学会誌 60 (4), 118-124, 2004
社団法人 繊維学会
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詳細情報 詳細情報について
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- CRID
- 1390282679806545408
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- NII論文ID
- 130004433651
- 10012886734
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- NII書誌ID
- AN00131651
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- ISSN
- 18842259
- 00379875
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- NDL書誌ID
- 6915439
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可