RADIATION-INDUCED GENE EXPRESSION IN HUMAN MALIGNANT GLIOMA CELL LINES AND RADIATION RESISTANCE

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  • 神経膠芽腫培養細胞の放射線照射による放射線耐性と遺伝子発現
  • シンケイコウガ シュ バイヨウ サイボウ ノ ホウシャセン ショウシャ ニ ヨル ホウシャセン タイセイ ト イデンシ ハツゲン

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Abstract

Survival cells after repeated irradiation may obtain radioresistance: this gene expression study aimed to identify the genes responsible for this radioresistance. After irradiation was administered five times (one cycle), radiation sensitivity was evaluated with cell growth curves, floating cell ratio and quantity of isolation LDH in the medium. The quantity of total irradiation indicated cell radioresistance. The results of these clonogenic assays show that cell radioresistance was confirmed even with a usual clinical irradiation of 60 Gy. Therefore, the quantity of total irradiation used in this study was 60 Gy. We detected five genes which showed changes of expression linked to radioresistance: reticulon 2, cyclin-dependent kinase 8, heterogeneous nuclear ribonucleoprotein K, tumor protein p53 binding protein 1, and farnesyl diphosphate synthase.

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