THE ROLE OF CENTRAL MONOAMINERGIC NERVOUS SYSTEMS IN THE FORMATION OF COLD STRESS-INDUCED ANALGESIA

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  • 寒冷ストレス誘発鎮痛の発現における中枢モノアミン作動性神経系の役割
  • カンレイ ストレス ユウハツ チンツウ ノ ハツゲン ニ オケル チュウスウ モノアミン サドウセイ シンケイケイ ノ ヤクワリ

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Abstract

To study the role of central nervous systems (noradrenergic, dopaminergic and serotonergic) in the formation of cold stress-induced analgesia [CSIA], quantitative changes in mono amines (noradrenarine [NE], dopamine [DA], serotonine [5-HT] ) and metabolites in the brain and spinal cord were measured by coulometric HPLC. CSIA was evaluated by the Tail flick latency method after exposure to environment at 4°C for 0.25, 0.5, 1 or 2 hrs. The quantitative changes in mono amines and the metabolites were measured in the brain (hypothalamus, midbrain-thalamus, medulla-pons) and the spinal cord (cervical cord, thoracic cord, lumber cord) of a cold stressed rat. CSIA was formed by exposure for 0.25 hr to cold stress. CSIA induced by 1 or 2 hrs exposure was significantly greater than that induced by 0.25 hr exposure. The noradrenergic nervous system in the medulla-pons, as well as activity of the serotonergic nervous system in the spinal cord was increased by exposure for 0.25 and 0.5 hr to cold stress. These findings suggest that the noradrenergic and/or serotonergic nervous system in the brain and the spinal cord may play a significant role in the formation of analgesia induced by short-term cold stress but not long term cold stress.

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