AN INVESTIGATION OF CLINICAL SIGNIFICANCE OF THE EXPRESSION Ki-67, p53 AND BCL-2 IN PROSTATE CANCER

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  • 前立腺癌におけるKi-67, p53, bcl-2の発現とその臨床的意義に関する検討
  • ゼンリツセン ガン ニ オケル Ki-67,p53,bcl-2 ノ ハツゲン ト ソノ リンショウテキ イギ ニ カンスル ケントウ

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We performed immunohistochemical analysis of human prostatic carcinoma using Ki-67, p53 and bcl-2. and determined them relationship to pathological and clinical findings on prostatic carcinoma. The subjects consisted of 50 prostatic carcinoma patients who underwent radical prostatectomy. We stained the tissue immunohistochemically with Ki-67, p53 and bcl-2 in operative specimens during radical prostatectomy. We evaluated the proliferative ability about Ki-67 after calculating the labeling index (Ki-67 positive cell/total cell ×100) . Bcl-2 staining was considered positive when tumor cells showed distinct cytoplasmic staining in>5% of cells. On the other hand, p53 staining was considered positive when tumor cells showed distinct nuclear staining in>5% of cells. As Ki-67 labeling index elevated significantly in non organ confined (invasion over capsel (+) ) and had a mutual relationship with the Gleason Score, our results suggest that Ki-67 immunostaining may be useful in predicting the proliferation of human prostate carcinoma. Howerer a higher Ki-67 index was obcerved in patients with lymphnode metastasis than in patients without. Bcl-2 and p53 did not show any significant correlaton with pathological findings.

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