SERUM AND IMMUNOHISTOLOGICAL STUDIES OF CEA, CA19-9 AND AFP IN GASTRIC CANCER

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  • 胃癌におけるCEA, CA19-9, AFPの臨床病理学的・免疫組織学的研究

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Serum CEA, CA19-9 and AFP concentrations were measured in 91 cases of gastric cancer, and immunohistology of resected tumor tissues and lymphonode was performed. Abnormally high levels of serum CEA, were observed in 2.3 cases (25.3%), of CA19-9 in 17 cases (18.7%), and of AFP in 4 cases (4.4%) . Combined assay with these tumor markers improved the positive rates to 26.3% in early and 47.2% in advanced stages of cancer. Positive immunochemical staining was observed in 83.5% of CEA, 46.3% of CA19-9, and 37.4% of AFP. Positive immunohistology of tumor markers was abnormally high in 100% of CEA, 82.4% of CA19-9, and 75% of AFP. In the staining localization patterns of tumor markers in cancer tissue, cytoplasmic or stromal types were highly concentrated in serum. In metastatic lymphnodes, 96.1% of CEA, 29.4% of CA19-9, and 70.6% of AFP were positive to immunohistological staining. In 9 recurrent cases, 4 cases of liver, 2 cases of peritoneum, 2cases of lymphnode, and 1 case of lung cancer abnormally high levels of serum tumor markers were observed in 77.8% of CEA, 44.4% of CA19-9, and 11.1% of AFP. Immunohistological examination was considered to have great value if cancer was still suspected in cases of negative serum tumor marker.

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