Sphingosylphosphorylcholine Concentration in the Cerebrospinal Fluid Is Increased after Subarachnoid Hemorrhage in Humans

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  • KUROKAWA Tetsu
    Department of Neurosurgery and Clinical Neuroscience, Yamaguchi University School of Medicine

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  • クモ膜下出血後の髄液中でｓｐｈｉｎｇｏｓｙｌｐｈｏｓｐｈｏｒｙｌｃｈｏｌｉｎｅの上昇が認められた～Ｓｐｈｉｎｇｏｓｙｌｐｈｏｓｐｈｏｒｙｌｃｈｏｌｉｎｅのｓｐａｓｍｏｇｅｎとしての可能性～
  • クモマッカ シュッケツゴ ノ ズイエキチュウ デ sphingosylphosphorylcholine ノ ジョウショウ ガ ミトメラレタ : Sphingosylphosphorylcholine ノ spasmogen トシテノ カノウセイ
  • クモ マク カ シュッケツ ゴ ノ ズイエキ チュウ デ sphingosylphosphorylcholine ノ ジョウショウ ガ ミトメラレタ Sphingosylphosphorylcholine ノ spasmogen ト シテ ノ カノウセイ

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 Cerebral vasospasm (CV) is one of the major causes of fatal complications after subarachnoid hemorrhage (SAH). The Ca2+ sensitization mechanism is currently considered to play an important role in the pathogenesis of CV. The authors previously reported that sphingosylphosphorylcholine (SPC) induces Ca2+-independent contraction in vascular smooth muscle. In the present study, we measured SPC concentration in the cerebrospinal fluid (CSF) of patients with SAH in order to elucidate the possible relationship between SPC and CV. <br> CSF was obtained from 9 patients with SAH after surgery. For comparison, SPC concentration in the CSF of one patient with meningioma and three patients with normal pressure hydrocephalus (NPH) was measured. The SPC concentration of CSF was 29.0±6.3 nM for SAH, whereas it was 2.7±4.6 nM for NPH. In the dog's SAH model and the SPC-injected model, SPC concentration did not increase significantly. These results suggest that SPC is released in CSF after SAH, but it is taken up to tissue immediately. Sphingosylphosphorylcholine in CSF after SAH probably released much more than the concentrations we measured in this study. With known contractile effect of SPC, it is highly possible that this molecule is one of the important mediators for CV after SAH.

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