THREE CASES OF SEVERE OCULAR COMPLICATION AFTER THE USE OF TOPICAL TOSUFLOXACIN

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  • AYAKI Masahiko
    Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine
  • YAGUCHI Shigeo
    Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine
  • KOIDE Ryohei
    Department of Ophthalmology, Showa University School of Medicine

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Other Title
  • トスフロキサシン点眼液によると思われる強い副作用を発症した3例
  • 臨床報告 トスフロキサシン点眼液によると思われる強い副作用を発症した3例
  • リンショウ ホウコク トスフロキサシン テンガンエキ ニ ヨル ト オモワレル ツヨイ フクサヨウ オ ハッショウ シタ 3レイ

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Abstract

We report three cases of adverse effects following the use of tosufloxacin ophthalmic solution. Case 1: An 88-year-old female visited our clinic with a corneal epithelial defect and was prescribed tosufloxacin ophthalmic solution 3 times daily. She returned complaining of whiteness in her cornea and a white corneal deposit was observed. The deposit was scraped off and she discontinued medication. Deposits were remarkably decreased on the following day. Case 2: A 78-year-old male with a herpetic corneal ulcer had a white corneal deposit after using ophthalmic solution containing tosufloxacin, atropin, and hyaluronic acid. The deposit decreased after discontinuation of the medication. Case 3: A 75-year-old female developed severe iritis after using tosufloxacin ophthalmic solution for conjunctivitis. The manifestation improved when medication and steroid therapy was discontined. The potential for a corneal deposit and iritis must be considered when prescribing tosufloxacin ophthalmic solution.

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