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- KOBORI Masao
- Department of Physiology, School of Medicine, Showa University
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- MERA Hitoshi
- Department of Physiology, School of Medicine, Showa University
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- TAKESHIGE Chifuyu
- Department of Physiology, School of Medicine, Showa University
Bibliographic Information
- Other Title
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- 針麻酔の鎮痛発現の中枢径路
- シン マスイ ノ チンツウ ハツゲン ノ チュウスウ ケイロ
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Abstract
The effect of acupuncture (AA) and 0.5 mg/kg morphine analgesia (MA) measured by rat tail-flick latency were completely abolished by restricted lesion of the dorsal periaqueduct central gray (d-PAG), the anterior (AH), posterior (PH) or lateral hypothalamus (LH), the lateral septum (l-Sep), dorsal hippocampus (d-HPC), habenulo-interpeduncular tract (HP) or medial centromedian nucleus of thalamus (mCM) or hypophysectomy. Sham lesions made slighly above or lateral these lesions did not abolish AA or MA. Stimulation of these regions, except hypophysis, caused long lasting analgesia after cessation of stimulation and these analgesias were completely antagonized by naloxone. Evoked potentials caused by acupuncture stimulation were recorded from these regions. d-PAG stimulation-produced analgesia (SPA) was abolished by lesion of AH, 1-Sep, d-HPC, HP or mCM or by hypophysectomy. Lesion of the HP abolished 1-Sep-SPA, d-HPC-SPA or mCM-SPA. The AH-SPA disappeared after hypophysectomy. The mCM-SPA was abolished by lesion of d-HPC. It was estimated that 0.5 mg/kg morphine analgesia might be caused by morphine activation of the acupuncture afferent pathway from d-PAG to hypophysis. From these results and our previous reports, acupuncture afferent pathways were as follows.
Journal
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- Journal of The Showa Medical Association
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Journal of The Showa Medical Association 41 (6), 619-628, 1981
The Showa University Society
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Details 詳細情報について
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- CRID
- 1390282679812004992
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- NII Article ID
- 130001825075
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- NII Book ID
- AN00117027
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- ISSN
- 21850976
- 00374342
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- NDL BIB ID
- 2478159
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed