A Case of Refractory Follicular Lymphoma Successfully Treated with Allogeneic Peripheral Blood Hematopoietic Stem Cell Transplantation following the Reduced Intensity Conditioning Regimen (RIST)

  • MATSUI Kumiko
    Division of Hematology, Department of Medicine, Yamaguchi Prefectural Medical Center
  • TANAKA Yoshinori
    Division of Hematology, Department of Medicine, Yamaguchi Prefectural Medical Center
  • MATSUDA Kazuhiro
    Division of Hematology, Department of Medicine, Yamaguchi Prefectural Medical Center
  • YAMASHITA Koji
    Division of Hematology, Department of Medicine, Yamaguchi Prefectural Medical Center
  • SHINOHARA Kenji
    Division of Hematology, Department of Medicine, Yamaguchi Prefectural Medical Center

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Other Title
  • 軽度な前処置による同種末梢血造血幹細胞移植(RIST)が有効であった難治性濾胞性リンパ腫の一症例
  • ケイドナ ゼンショチ ニヨル ドウシュ マッショウ ケツゾウ ケッカン サイボウ イショク RIST ガ ユウコウ デアッタ ナンチセイ ロホウセイ リンパシュ ノ イチショウレイ
  • 症例報告 軽度な前処置による同種末梢血造血幹細胞移植(RIST)が有効であった難治性濾胞性リンパ腫の一症例
  • ショウレイ ホウコク ケイド ナ マエショチ ニ ヨル ドウシュ マッショウケツ ゾウケツ カンサイボウ イショク RIST ガ ユウコウ デ アッタ ナンジセイ ロホウセイ リンパ シュ ノ イチ ショウレイ

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Abstract

Follicular lymphoma in a 31 years-old female was refractory to repeated conventional chemotherapies. She had cardiac dysfunction due to the regimen related toxicity of chemotherapy. She received allogeneic peripheral blood stem cell transplantation following the reduced intensity conditioning regimen with melphalan and cladribine. Hematopoietic recovery after transplantation was prompt, and complete chimerism was obtained. The patient had not acute or chronic graft versus host disease. Lymphoma was in complte remission for a year until the swelling of neck lymphnode which disappeared after the withdrawal of cyclosporine. The patient enjoyed good quality of life after transplantation.

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