EFFECTS OF ENDOMORPHINS ON THE MOTILITY OF THE LARGE INTESTINE IN RATS

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  • ラット大腸運動に対するEndomorphinsの影響
  • ラット ダイチョウ ウンドウ ニ タイスル Endomorphins ノ エイキョウ

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Abstract

The two novel endogenous peptides, endomorphin-1 and -2 were found by Zadina et al in 1997. Both of these endomorphins are selective mu opioid receptor agonists. In the present study the effect of endomorphins on the motility of the large intestine in rats was examined. In chloralose anesthetized male Wistar rats (280-380g), spontaneous motility of the large intestine was monitored by recording the pressure of a balloon inserted 5 cm into the large intestine from the anus. Both endomorphins administered intravenously inhibited the motility of the large intestine dose dependently (10 nmol/kg-100 nmol/kg) . Inhibition of the motility lasted for 2 to 6 minutes at a dose of 10 nmol/kg. These inhibitory effects were completely antagonised by pre-administration of Naloxone (2 mg/kg) . However, the site of inhibitory action of the endomorphins has not been clarified. The effects of endomorphins and morphine on the motility of the resected large intestine were examined in rats. The spontaneous motility of the large intestine, which was resected at a level of 5 cm rostal from the anus in Krebs solution, was monitored. Motility of the resected large intestine was not inhibited by administration of endomorphins and morphine in Krebs solution. The results suggest that endomorphins inhibit motility of the large intestine through inhibition of neural activities.

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