A Case of Effective Combination Therapy Involved Hepatectomy and Transhepatic-arterial Chemotherapy for Multiple Liver Metastases after Suffering from Multiple Bone Metastases of Breast Cancer.

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  • 乳癌術後の多発性骨転移治療後に，多発肝転移を来し肝切除，肝動注療法を含む集学的治療を行った１例
  • ニュウガン ジュツゴ ノ タハツセイ コツ テンイ チリョウゴ ニ タハツ カン テンイ オ キタシ カン セツジョ カン ドウチュウ リョウホウ オ フクム シュウガクテキ チリョウ オ オコナッタ 1レイ
  • 症例報告 乳癌術後の多発性骨転移治療後に,多発肝転移を来し肝切除,肝動注療法を含む集学的治療を行った1例
  • ショウレイ ホウコク ニュウガン ジュツゴ ノ タハツセイコツ テンイ チリョウ ゴ ニ タハツ カン テンイ オ キタシ カン セツジョ カンドウ チュウ リョウホウ オ フクム シュウガクテキ チリョウ オ オコナッタ 1レイ

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The patient was a 36-year-old woman who had undergone modified radical mastectomy for right breast cancer in November 2005. An LH-RH agonist and tamoxifen were administered, but metastasis was found in the right femoral bone, so six cycles of EC therapy were administered. A partial response was achieved, but the bone metastasis worsened in June 2007, so administration of docetaxel and trastuzumab was added. This treatment was continued because a partial response was achieved, but metastatic tumors appeared in the lateral region of the left lobe of the liver in April 2008, and they had grown bigger by July 2008, so we changed docetaxel to vinorelbine administered for 2 weeks, followed by a week of rest. Serum LDH and CA15-3 levels began to increase in August 2008, and the metastatic tumors showed marked enlargement, so we performed hepatectomy and inserted an indwelling catheter in the hepatic artery in October 2008. After the operation, a combination of hepatic intra-arterial epirubicin every week and systemic irinotecan every 2 weeks with trastuzumab every week was begun and is ongoing. As of January 2009, 3 months after the operation, the outcome has been good, with no recurrence or metastatic lesions seen on PET-CT.

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