Thiamineの脳室内投与における血圧変化について

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タイトル別名
  • EFFECT OF THIAMINE ON BLOOD PRESSURE BY INTRAVENTRICULAR INJECTION
  • Thiamine ノ ノウシツナイ トウヨ ニ オケル ケツアツ ヘンカ ニ

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抄録

The effects of thiamine (B1), its related substances and histamine liberators on blood pressure were studied by intraventricular injection to the rats. The results were as follows :<BR>1) The lasting rise of blood pressure was observed by the injection of B1 (50 to 200μg/animal), thiaminic acid (200μg), desthiothiamine (200μg) and cocarboxylase (CoC, 10μg) . The similar effect was observed by the injection of histamine liberators such as compound 48/80 (0.01μg), polymyxin B (0.01μg) and d-tubocurarine (0.5μg) .<BR>2) This pressure rising effect of B1, CoC and histamine liberators was inhibited by the pre-treatment with 20μg of antihistaminics (tripelennamine) . The pre-treatment of procaine (0.01 μg) did not inhibited effect of B1and CoC.<BR>3) Each successive injections of B1, thiamine tetrahydrofurfuryl disulfide (TTFD), CoC and histamine liberators caused tachyphylaxis.<BR>4) Polymyxin B and B1or d-tubocurarine produced cross-tachyphylaxis, which also occurred in the case of d-tubocurarine and B1, TTFD or polymyxin B.<BR>From these results, it seemd that the blood pressure rising effect by the injection of B1and its related substances may be ascribed to the histamine releasing action of these substances.

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