人血漿cholinesteraseの筋弛緩薬に及ぼす基礎的および臨床的研究

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  • BASIC AND CLINICAL STUDIES ON THE EFFECTS OF HUMAN PLASMA CHOLINESTERASE UPON MUSCLE-RELAXANTS
  • ジン ケッショウ cholinesterase ノ キン シカンヤク ニ オヨ

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Basic and clinical studies were performed on the effects of human plasma cholinesterase (pChE) preparation upon succinyl choline chloride (SCC) with dogs and surgical patients. The results revealed the following.<BR>1. Six units/kg of pChE preparation elevated pChE activity of dogs significantly.<BR>2. Six units/kg of pChE preparation significantly reduced and shortened the muscle relaxant effects of SCC in dogs.<BR>3. Significant rise in pChE activity was noted in humans with 2, 4 and 8 units/kg of pChE preparation<BR>4. Two units/kg of pChE preparation administered to humans once elevated pChE activity, which returned to the original level within 5 minutes, whereas 4 and 8 units/kg could maintain the activity level for more than 3 hours<BR>5. The effect of SCC was distinctly reduced and shortened in humans by administration of 2, 4 and 8 units/kg of pChE preparation.<BR>6. Unless the SCC, which had been previously administered several times, induced the state of phase II blocking, the effects of pChE preparation were not adversely affected<BR>7. The pChE preparation did not show any specificity to species when administered to humans and dogs.<BR>8. No side effect was seen by pChE preparation in the circulatory systems of humans or dogs.<BR>From the above-mentioned results, it could be assessed that positive efficacy could possibly be expected by pChE preparation against prolonged apnea with SCC or reduced pChE activity in humans.

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