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- Arai Akira
- Department of Pharmacology, School of Medicine, Showa University
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- Amemiya Hisao
- Department of Pharmacology, School of Medicine, Showa University
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- Namatame Eiichi
- Department of Pharmacology, School of Medicine, Showa University
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- Shimizu Noriyuki
- Department of Pharmacology, School of Medicine, Showa University
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- Nishijima Tatsuro
- Department of Pharmacology, School of Medicine, Showa University
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- Arai Mitsuko
- Department of Pediatrics, National Daiichi Hospital
Bibliographic Information
- Other Title
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- Nivalineの抗Cholinesterase作用
- Nivaline ノ コウCholinesterase サヨウ
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Abstract
Nivaline is an alkaloid extracted from Galanthus nivalis L. and chemically, the same as Galanthamine. Nivaline showed potent anti-cholinesterase activity and used for a remedy of the treatment of myoparalysis clinically, such cases as poliomyelitis and myasthenia gravis etc.<BR>We have studied the relationship between the anti-cholinesterase activity and the effect of Nivaline as a remedy of the treatment of poliomyelitis. The following results were obtained.<BR>1) Cholinesterase (ChE) activity in blood of patients suffering from acute anterior poliomyelitis following the administration of 0.25 mg, 0.5mg and 2.5mg of Nivaline is almost the same as the control.<BR>2) In vitro, 10-4-10-5 M of Nivaline inhibited 50% of the specific and non-specific ChE activity.<BR>3) ChE activity in brain and in liver of rat and mouse following the administration of Nivaline is almost the same as the control.
Journal
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- Journal of The Showa Medical Association
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Journal of The Showa Medical Association 28 (3), 156-161, 1968
The Showa University Society
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Details 詳細情報について
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- CRID
- 1390282679815445248
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- NII Article ID
- 130001821682
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- NII Book ID
- AN00117027
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- COI
- 1:CAS:528:DyaF1cXkslGmtrk%3D
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- ISSN
- 21850976
- 00374342
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- NDL BIB ID
- 8250884
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed