書誌事項
- タイトル別名
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- PHARMACOLOGICAL STUDIES OF DIISOPROPYL 1, 3-DITHIOL-2-YLIDENE MALONATE (NKK-105) REPORT 1
- Diisopropyl 1,3-dithiol-2-ylidene melonate(NKK-105)の薬理学的研究-1-一般薬理作用
- Diisopropyl 1 3 dithiol 2 ylidene melon
- GENERAL PHARMACOLOGICAL ACTIVITIES
- 一般薬理作用
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We have investigated the general pharmacological activities of diisopropyl 1, 3-dithiol-2-ylidene malonate (NKK-105), and obtained the following results.<BR>1. NKK-105 has shown a transient inhibitory effect on respiration, and lowering of blood pressure in rabbits by intravenous injection by a dose of over 10 mg/kg.<BR>2. It has shown an inhibitory effect on the isolated hearts of guinea pigs with a dose of over 1×10-5g/ml, and had no effects upon preatroinization.<BR>3. It has also shown a same inhibitory effect on the isolated smooth muscles of guinea pig trachial muscle, rabbit ileum, guinea pig ileum, rat uterus and guinea pig vas def erens with a dose of over 1×10-6-1×10-5 g/ml. Muscle contraction induced by acetylcholine, nicotine, oxytocin, noradrenaline and barium chloride or electrical stimulation has been inhibited with pretreatment of NKK-105.<BR>4. On the intestinal ability to transport charcoal meal in the intestine of mice, it has also shown an inhibitory effect with a dose of over 100 mg/kg.<BR>5. NKK-105 has increased excretion of urine and electrolytes in mice and rats with a dose of 10, 50 mg/kg, p.o., however, it has shown an inhibitory tendency with a dose of over 250 mg/kg, p.o.. Additionally, NKK-105 has never had any effect on serum electrolytes with a dose 500 mg/kg, p.o..
収録刊行物
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- 昭和医学会雑誌
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昭和医学会雑誌 38 (3), 315-322, 1978
昭和大学学士会
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詳細情報 詳細情報について
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- CRID
- 1390282679815473792
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- NII論文ID
- 130001823218
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- NII書誌ID
- AN00117027
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- ISSN
- 21850976
- 00374342
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- NDL書誌ID
- 2073141
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可