ニワトリに対するVitamin B<SUB>1</SUB>大量投与について

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タイトル別名
  • EFFECT OF LARGE AMOUNTS OF THIAMINE ON FOWL
  • ニワトリに対するVitamin B1大量投与について
  • ニワトリ ニ タイスル Vitamin B1 タイリョウ トウヨ ニ ツイテ

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抄録

Large amounts of thiamine (300-700 mg/kg) was injected subcutaneously to fowl for consecutive 30 days. The following results were obtained.<BR>1. Body weight decreased slightly.<BR>2. The 24 hours urines after injection were collected and determined the contents of thiamine in these urines. The percentage of thiamine excreted to the amounts administered was less than 50%. The urinary excretion of 2-methyl-4-amino-5-hydroxymethylpyrimidine, component of thiamine and its oxidative product, 2-methyl-4-aminopyrimidyl-5-carboxylic acid were not observed.<BR>3. Moderate degenerative histopathological change was detected in the liver and lung, -whereas no remarkable change in gallbladder, pancreas and spleen.<BR>4. No appreciable effect was observed on kidney-anserinase activity of the fowl.

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