実験的大腸菌感染症に及ぼすShizophyllan, 制癌剤及び免疫抑制剤の効果

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  • EFFECT OF SCHIZOPHYLLAN, IMMUNOSUPPRESSANTS AND ANTITUMOR SUBSTANCES ON EXPERIMENTAL <I>ESCHERICHIA COLI INFECTION</I>
  • ジッケンテキ ダイチョウキン カンセンショウ ニ オヨボス Shizophyl

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Nonspecific protection of mice against experimental E. coliinfection is stimulated by the pretreatment with schizophyllan (SPG), a glucan produced by Schizophyllum commune. An immunosuppressant or antitumor substance was administered, before or immediately after the challenge with E. coli, to the SPG-treated or non-treated mice, and the influences of the drugs on the protection test was examined.<BR>(1) The protective activity of mice proved to increase by the treatment with 6-mer-captopurine alone immediately after the challenge.<BR>(2) The protective activity of mice increased by the pretreatment with actinomycin D, bleomycin, adriamycin or antilymphocyte serum alone.<BR>(3) The protective activity increased by the administration of cyclophosphamide, azathioprine, 5-fluorouracil or bleomycin immediately after the challenge in the SPG-treated mice.<BR>(4) The decrease of the protective activity was recognized by the administration of actinomycin D, chromomycin A3 or antilymphocyte serum immediately after the challenge in the SPG-treated mice.<BR>(5) The increase of protective activity was observed by the combined pretreatment with SPG-cyclophosphamide, SPG-chromomycin A3 or SPG-antilymphocyte serum.<BR>(6) The decrease of protective activity in SPG-treated mice was seen by the administration of 6-mercaptopurine, 5-fluorouracil or dexamethasone before the challenge.<BR>(7) No remarkable influence on the protection was demonstrated by the treatment with cytosine arabinoside, mitomycin C or L-asparaginase before or after the challenge.

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